I hear you owe that boy a SIGNIFICANT debt.
Game of Thrones Season 3, Episode 3
...I'm going to go do work
that promises SIGNIFICANT results...
The Big Bang Theory Season 2, Episode 2
If I had another SIGNIFICANT aspect
of my life...
The Big Bang Theory Season 2, Episode 3
...to make any SIGNIFICANT contribution
to physics played a trick on you.
The Big Bang Theory Season 2, Episode 6
with his SIGNIFICANT other.
The Big Bang Theory Season 7, Episode 5